Chicago, United States The Seneca Hotel & Suites is an intimate escape, just a block off Chicago's Magnificent Mile. Here, you'll discover a quaint, European style hotel, treasured by those who prefer a quiet tree-lined street, and an elegant, spacious suite. In the shadow of the John Hancock Center and Water Tower Place, you'll be within walking distance to the finest shopping, dining & entertainment that Chicago has to offer. Mostly, suites priced like rooms, you will feel at home with spacious living room & dining areas, fully equipped kitchens and separate bedrooms. At the Seneca, you'll be in the middle of everything- yet away from it all.